pI: 6.9944 |
Length (AA): 746 |
MW (Da): 81679 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
305 | 646 | 3nyb (A) | 160 | 479 | 28.00 | 0 | 1 | 0.782145 | -0.15 |
318 | 669 | 5w0b (A) | 995 | 1359 | 21.00 | 0.00000014 | 1 | 0.56755 | 0.33 |
327 | 616 | 3nyb (A) | 182 | 455 | 34.00 | 0 | 1 | 0.75104 | -0.2 |
630 | 741 | 4ig8 (A) | 4 | 120 | 12.00 | 0.000078 | 0.03 | 0.232834 | -0.11 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127416)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G53770 | nucleotidyltransferase family protein |
Babesia bovis | BBOV_III006620 | hypothetical protein |
Brugia malayi | Bm1_48580 | PAP/25A associated domain containing protein |
Candida albicans | CaO19.8059 | Mitotic chromosome condensation |
Candida albicans | CaO19.429 | Mitotic chromosome condensation |
Caenorhabditis elegans | CELE_ZK858.1 | Protein GLD-4 |
Cryptosporidium hominis | Chro.70404 | hypothetical protein |
Cryptosporidium parvum | cgd7_3630 | TRF4/5 nucletotidyl transferase |
Dictyostelium discoideum | DDB_G0295737 | PAP/25A-associated domain-containing protein |
Drosophila melanogaster | Dmel_CG11265 | CG11265 gene product from transcript CG11265-RE |
Echinococcus granulosus | EgrG_000623000 | nucleotidyltransferase |
Entamoeba histolytica | EHI_087330 | topoisomerase, putative |
Entamoeba histolytica | EHI_003910 | hypothetical protein, conserved |
Entamoeba histolytica | EHI_073170 | topoisomerase, putative |
Echinococcus multilocularis | EmuJ_000623000 | nucleotidyltransferase |
Giardia lamblia | GL50803_16285 | Topoisomerase I-related protein |
Homo sapiens | ENSG00000121274 | PAP associated domain containing 5 |
Homo sapiens | ENSG00000112941 | PAP associated domain containing 7 |
Leishmania braziliensis | LbrM.07.0770 | topoisomerase-related function protein-like protein |
Leishmania donovani | LdBPK_070780.1 | topoisomerase-related function protein-like protein |
Leishmania infantum | LinJ.07.0780 | topoisomerase-related function protein-like protein |
Leishmania major | LmjF.07.0700 | topoisomerase-related function protein-like protein |
Leishmania mexicana | LmxM.07.0700 | topoisomerase-related function protein-like protein |
Loa Loa (eye worm) | LOAG_05671 | PAP/25A associated domain-containing protein |
Mus musculus | ENSMUSG00000034575 | PAP associated domain containing 7 |
Mus musculus | ENSMUSG00000036779 | PAP associated domain containing 5 |
Neospora caninum | NCLIV_043710 | hypothetical protein, conserved |
Oryza sativa | 4325901 | Os01g0672700 |
Plasmodium berghei | PBANKA_1347200 | nucleotidyltransferase, putative |
Plasmodium falciparum | PF3D7_1332400 | nucleotidyltransferase, putative |
Plasmodium knowlesi | PKNH_1268200 | nucleotidyltransferase, putative |
Plasmodium vivax | PVX_082550 | hypothetical protein, conserved |
Plasmodium yoelii | PY05727 | topoisomerase-related function protein |
Saccharomyces cerevisiae | YOL115W | non-canonical poly(A) polymerase PAP2 |
Saccharomyces cerevisiae | YNL299W | non-canonical poly(A) polymerase TRF5 |
Schistosoma japonicum | Sjp_0133600 | ko:K03514 DNA polymerase sigma subunit, putative |
Schistosoma japonicum | Sjp_0309770 | expressed protein |
Schistosoma mansoni | Smp_145600 | hypothetical protein |
Schmidtea mediterranea | mk4.002515.01 | |
Schmidtea mediterranea | mk4.005006.01 | |
Schmidtea mediterranea | mk4.005006.00 | |
Trypanosoma brucei gambiense | Tbg972.8.650 | DNA polymerase sigma, putative |
Trypanosoma brucei | Tb927.8.1090 | NPAPL |
Trypanosoma congolense | TcIL3000_8_690 | DNA polymerase sigma, putative |
Trypanosoma cruzi | TcCLB.508543.10 | DNA polymerase sigma, putative |
Trypanosoma cruzi | TcCLB.506401.100 | DNA polymerase sigma, putative |
Toxoplasma gondii | TGME49_210440 | polynucleotide adenylyltransferase |
Theileria parva | TP02_0312 | hypothetical protein |
Trichomonas vaginalis | TVAG_080950 | Poly(A) RNA polymerase protein, putative |
Trichomonas vaginalis | TVAG_314620 | trf5, putative |
Trichomonas vaginalis | TVAG_490130 | PAP-associated domain-containing protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.1090 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.1090 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.1090 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.8.1090 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_ZK858.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_ZK858.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_ZK858.1 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1347200 | Plasmodium berghei | Slow | plasmo |
TGME49_210440 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.